Friday, March 20, 2026

Amazing Art - Helicline Fine Art at The American Art Fair (5/16-5/19, NYC)

 Helicline Fine Art will present a dynamic selection of historic American paintings, drawings, and sculptures at The American Art Fair, May 16–19, at Bohemian National Hall (431 East 73rd Street, between First and Second Avenues).

Founded in 2008 by Keith Sherman and Roy Goldberg, Helicline Fine Art is devoted to American and European Modernism, with particular emphasis on the Works Progress Administration (WPA) era of the 1930s and 1940s - a defining period in which American art became a public trust. During the Great Depression, federal programs such as the WPA and Federal Art Project (FAP) supported thousands of artists, fostering a generation that chronicled American life with social consciousness and optimism.


Sherman and Goldberg have championed artists, both celebrated and those under-the-radar, who captured the rhythms of modern life from city streets and factory floors to workers, families, and moments of exuberant joy. Their lovingly built collection reflects an era when American art stepped confidently onto the world stage, synthesizing Social Realism, Regionalism, Abstraction and other genres, into a distinctive voice: the American Scene.


Helicline’s current exhibition, Showstoppers: The Art of Stage and Screen, is online now through May 10. More than three dozen costume and set design drawings, illustrations, sculptures and paintings spanning the 1920s through the 90s, show the spectacle of Broadway, film, dance, opera, and popular entertainment. Some represented productions include: Cat on a Hot Tin Roof, My Fair Lady, Funny Girl, Sweet Charity, West Side Story, The King and I, Bye Bye Birdie, The Wiz, Anything Goes, OpĂ©ra de Paris, Phantom of the Opera, South Pacific, The Pajama Game, Follies, and the legendary nightlife of Studio 54.


ABOUT HELICLINE FINE ART

Founded in 2008 by Roy Goldberg and Keith Sherman, Helicline Fine Art specializes in American and European modernism, with particular strength in WPA-era works. The gallery also presents American Scene painting, Social Realism, mural studies, industrial landscapes, Regionalism, abstraction, and related movements. Located in a private Midtown Manhattan space, Helicline Fine Art is open by appointment.

 

Works are available through HeliclineFineArt.comArtsy.net and 1stDibs.com.


ABOUT THE AMERICAN ART FAIR

The American Art Fair returns to the elegant, landmarked Bohemian National Hall May 16 - 19, 2026 with 18 preeminent exhibitors specializing in American art by nonliving artists. Celebrating its 19th year, and the country’s 250th anniversary, the event offers hundreds of paintings, prints, drawings and sculpture from the 18th to the 21st centuries. www.theamericanartfair.com

 

Admission is free. Collectors, curators and the curious can explore exemplary offerings of works by Hudson River artists, American Impressionism, Surrealism, Regionalism, Modernism, Postwar Abstraction, and more.

 

The Fair’s founder Tom Colville notes: “The American Art Fair is unique in its focus on historical American art in a relaxed and intimate setting where visitors can interact with the leading dealers in the field. The combined expertise of our exhibitors is unmatched. Their knowledge and experience draw curators and collectors to Manhattan in May to celebrate American art”.

 

House & Home - Are You Backyard Ready for Spring?

 Your family yard is an extension of your home – providing a respite from stress, offering an outside entertainment area, expanding your living space, and giving kids and pests a safe place to play. Here are TurfMutt’s top tips!

Take Stock of Tools: 
Do you need to replace your outdoor power equipment (lawn mower, leaf blower, trimmer, etc.?) Want to install a smart irrigation system? Plan now so you’re ready! 

Remember Wildlife and Pollinators: 
Nature starts at your backdoor. Grass, trees, shrubs, and flowering plants provide food and habitat for birds, small mammals and pollinators, plant accordingly. 

Plant for Kids and Pets: 
There are many species of turfgrass. Your local garden center or landscaper can help you identify what will work best. 

Plan for Fun: 
You might want an outdoor room fire pit, pergola, sandbox, outdoor furniture or a decorative water feature, furniture, or a decorative water feature. 



For more information visit www.turfmutt.com 

About the TurfMutt Foundation
TurfMutt, which celebrated its 15th anniversary in 2024, was created by the Outdoor Power Equipment Institute’s (OPEI) TurfMutt Foundation and has reached more than 70 million children, educators and families since 2009. The Foundation is title sponsor of “Lucky Dog,” the Emmy Award-winning CBS broadcast television show in support of dog rescue and rehabilitation. Both TurfMutt spokesdogs have been rescue dogs, and Mutt Mulligan is a cast character on the show, where her “Mulligan Minute” segments teach viewers about the benefits of green space. In 2024, the Great Lawn at Louisville’s award-winning Waterfront Park on the Ohio River was renamed the TurfMutt Foundation Great Lawn as part of a $1 million sponsorship. Championed by Mulligan the TurfMutt, and through education partners such as Scholastic, Discovery, Weekly Reader, and the USBGC Global Learning Lab, TurfMutt has taught students and teachers how to “save the planet, one yard at a time.” TurfMutt has been an education resource at the U.S. Department of Education’s Green Ribbon Schools, the U.S. Department of Energy, the U.S. Environmental Protection Agency, Green Apple, the Center for Green Schools, the Outdoors Alliance for Kids, the National Energy Education Development (NEED) project, Climate Change Live, Petfinder and the U.S. Fish and Wildlife Service. In 2017, the TurfMutt animated video series won the coveted Cynopsis Kids Imagination Award for Best Interstitial Series. More information at www.TurfMutt.com.


Money Matters - Home Ownership Survey

Homeownership is often framed as part of the American dream, but the reality is that many feel overwhelmed by the constant upkeep and unexpected costs. A new report from American Home Shield finds that the majority of homeowners (64%) say owning a home is stressful.

Key insights include:

  • 74% worry about how they will afford home repairs
  • 69% say home repairs are actively “overwhelming” them
  • In 12 states, radon exposure ranked as homeowners’ biggest home-related stressor

The financial toll is also significant. In 2025, homeowners spent an average of $3,737 on repairs, and 18% went into debt to cover those costs. To cope, many are turning to DIY solutions—78% say they’ve attempted repairs themselves, with 67% relying on online tutorials to figure out how to fix issues around the house.

Take a look at the full report for more insights into the costs, anxieties, and repair trends shaping homeownership today

Music Minute - 2027 Ultimate Disco Cruise and Beyond

After another incredible sold out sailing in 2026, StarVista LIVE returns with the 7th installment of the Ultimate Disco Cruise and Beyond with an already star-studded lineup of superstars including Kool & the Gang, Gloria Gaynor, The Spinners, Jody Watley, Russell Thompkins, Jr. & The New Stylistics, Al McKay’s Earth, Wind, and Fire Experience, Lisa Lisa, The Trammps featuring Earl Young, and many more! Hitting the high-seas on February 21st from Ft. Lauderdale and stopping in Grand Turk and Puerto Plata before returning on February 26, 2027.

“The Ultimate Disco Cruise has evolved over the years and we are thrilled each year to bring the biggest names to perform and entertain our cruisers,” says Alan Rubens, executive producer. “With the limited number of disco artists still touring, we have started adding artists a little ‘beyond’ the disco era and our patrons have been loving every performance that we introduce to this cruise.”


With over 34 #1 hits among the performers, cruisers will be offered the best in disco, dance, soul, funk, and party music and even more artists will be added throughout the year, so stay tuned for updates.


The Ultimate Disco Cruise and Beyond offers music fans the ultimate immersive disco and dance music experience while onboard the luxurious Celebrity Silhouette, all set to a nonstop disco soundtrack, from thrilling live performances and DJ sets to artist panels, dance lessons, wine tastings, dancing ‘til dawn at nightclub Studio 55, and more!


Fares for the remaining cabins available start at $2,900 per person and include admission to all concerts, parties and events, as well as all meals.


For further information on the Ultimate Disco Cruise or to book a cabin, please call 844-296-3472 or visit ultimatediscocruise.com.


About StarVista LIVE:

StarVista LIVE creates unique entertainment experiences that bring fans together to relive their favorite moments, create new memories, and enjoy unparalleled access to the superstars they love. StarVista LIVE cruise events include the Malt Shop Memories Cruise, two Soul Train Cruises, the Country Music Cruise, the Flower Power Cruise, the ‘70s Rock and Romance Cruise, the Sandy Beaches Cruise, the Ultimate Disco Cruise and Beyond, and the Big Easy Cruise.

Thinking Tech - Phone Notification Survey

As we know, there's no ignoring our tech devices, and for parents, it's a tough push and pull since kids see everything.

 

Americans in 40 major cities were recently surveyed about their experience of notification fatigue. We asked how often they’re interrupted, what notifications are most tiresome, and how they’re battling back against the onslaught of notifications. The data proves just how much parents have to balance while trying to be present with their families.


Call out data:


  • 1 in 5 Americans say their habit of checking notifications immediately has impacted their relationships.

  • Nearly 2 in 5 Americans say their notifications have caused them to ignore someone who was talking to them in person. 

  • 66% of Americans are interrupted at least once an hour by notifications, and 1 in 3 are interrupted every 20 minutes.

  • More than two-fifths of Americans say they frequently receive notifications from group chats.

  • 1 in 2 Americans receive more than 20 notifications on their phone each day. 

Caring Connections - The Malnourished Marriage

Every 16 seconds, a marriage takes place in the United States — more than 2 million each year. Yet every 42 seconds, a divorce happens — nearly 750,000 annually. In the time it takes a couple to recite their wedding vows, nearly three marriages end. During a typical romantic comedy, more than 170 couples will divorce. Why do so many marriages fail? And could most of them have been saved?

According to Nancy Perpall, the answer is yes.

Perpall is a former divorce attorney and former nurse — and she says something surprising: during her decades practicing family law, over 90% of the divorces she handled were preventable. Most couples weren’t ending their marriages because of betrayal, abuse, or a single catastrophic event. Instead, their relationships were slowly deteriorating from what she calls “emotional malnutrition.”
In her new book, The Malnourished Marriage, Perpall combines her legal and medical backgrounds to explain how marriages fail — and how they can be saved. She compares relationships to the human body, arguing that just as physical health depends on essential nutrients, so does marital health.

She identifies five essential emotional nutrients every marriage needs to survive:
• Communication (water)
• Sexual connection (protein)
• Humor (carbohydrates)
• Compromise (healthy fats)
• Trust (multivitamins)

When one or more of these emotional nutrients is missing, she says, the relationship weakens — often slowly and quietly — until couples believe divorce is the only option.

Ironically, Perpall says she often tried to talk clients out of divorce, which ultimately inspired her to write the book and create what she calls a “marriage health checkup” to help couples identify problems before it’s too late.

I had a chance to interview her to learn more.

Tell us about your book.
The Malnourished Marriage: 5 Emotional Nutrients For A Healthy Relationship uses the communicative power of food as the universal language for what a corrosive effect on the relationship avoids intense bickering and cold standoffs that lead to contempt, the biggest predictor of divorce. A relationship needs to be healthy. Anyone who's been married or in an intimate relationship knows that you can’t take words back once they’ve been said or screamed. They also know that harsh words have a way of permeating all aspects of the relationship. Sex? You want me to have sex with you after what you just said to me? This book explains that a relationship is a separate entity that needs certain emotional nutrients to be healthy, just as the human body requires certain physical nutrients. By using the metaphor of food to describe to a spouse or partner what you feel is missing in the relationship can reduce anxiety about thee topic. On the other hand, using harsh words can have such a corrosive effect on your partner that they begin to question why they’re in the relationship.

What led you to write the book?
After watching clients proceed with divorce over verbal misunderstandings that caused them to act out by treating the other with disrespect, disdain, mockery, name-calling, aggressive humor, and sarcasm, I knew there had to be a better way for a couple to communicate what is bothering them.

What was the hardest challenge in writing it?
Doing all the research to make sure that my theory that a relationship becomes how you think about it was backed up by neuroscience – and it is. Using your brain to change a relationship is not a quick fix, but it is a permanent one.

How do you feel your background as a nurse and a family law attorney made you uniquely qualified to tackle this subject?
As a nurse, I saw love die in hospital rooms, and as a divorce lawyer, I saw it die in courtrooms. As a nurse, I learned about the physical nutrients needed to maintain the body’s health. As a family law attorney, I learned the emotional nutrients that it takes to maintain a healthy relationship.

Why might so many people not realize that many divorces are preventable?
Because of the intense social focus on romantic love, when the early feelings of romance fade, partners feel as if they have fallen out of love. I believe this is due to the unrealistic romantic expectations of a long-term commitment to the same person fostered by the “Happily Ever After” myth. Many couples are not taught how to navigate their disagreements, modeling how their parents resolved or did not resolve theirs. Unfortunately, with the rise of no-fault divorce, too many couples view their inability to resolve a conflict as a sign of incompatibility, rather than realizing that love is a long-term commitment that requires active ongoing effort, and their conflicts could be resolved by changing relationship patterns, by changing the way they think about the relationship. That is, as a separate entity. By treating the relationship as an independent, shared project, partners can reduce personal blame and focus on the health of their connection rather than just individual needs. Just as the body is one unit connected by different parts, the relationship is one unit connected by the parties in it. Each part of the body serves a different function, just as each need of the relationship serves a different function.

Why do you compare relationship skills to nutrients?
What I’ve seen in my practice as a family lawyer is that when I connected the advice I was giving to a client to something they already knew, it gave the advice an instant attention-grabbing ability and made it easier for the client to remember the advice when they were in a situation where it could be applied.

For example, a client came in for a divorce consult, explaining that he “couldn’t take it anymore.”

“The way my wife talks to me. She knows there are words that she uses that trigger a reflexive response of anger on my part, but she doesn’t seem to get it.”

Nodding my head, I responded, “I get it. The thing is, words are a lot like water; they can crash, or they can flow. A relationship needs communication just like the body needs water. A human can only live three days without water, and while a relationship can last more than three days without the parties communicating with each other, the relationship becomes dehydrated.”

His face softened as his lips turned up slightly at the corners. “Yeah, when you put it that way, I’m parched.”

“Well, you came in here looking for information about getting divorced. Would you like some suggestions about how to avoid getting one?”

“I’ve been studying the reasons couples give for getting divorced. I’ve learned that a marriage breaks down when there’s not enough communication, sex, humor, compromise, or trust. These are the emotional nutrients the relationship needs to be healthy. Just like the body will break down when it doesn’t get enough water, protein, carbohydrates, healthy fats, and the right vitamins.”

“So you compare the emotional nutrients a relationship needs to the nutrients a body requires.”

“But how does that work?”

“In a relationship, I compare water to communication, protein to sex, carbohydrates to laughter and play, healthy fats to compromise, and trust to a multivitamin. “Indeed, of using words like ‘We need to talk,' which sounds like a demand, you say something like ‘I feel as if our relationship is dehydrated.’ Instead of saying something like, ‘We never have sex anymore.’ Which sounds like a complaint, explain that semen is pure protein, and say something like, What do you think about having to have some deep protein therapy. It’s better than taking collagen for your skin.”

“Can I read more about this?” he asked.

“Well, it just so happens that I have a draft of the book I’m writing about it, so if you are interested, I’ll give you a copy if you’ll agree to give me your feedback. What’s good and what needs work.”

“If you’d like to proceed with the divorce, my secretary will make another appointment for you.”

He waited a long moment, rubbed his chin, and said, “I’d like to read this first and think about things.”

“ Good plan, since I’ve seen a lot of clients start and then stop a divorce to see if they can get back together. But once you start the process of divorce without addressing what caused the divorce, like communication, sex, incompatibility, lack of trust, no matter how much you may want to get back together, you will be back together exactly where you were before the divorce. I personally haven’t seen it work very well.”

In summary, using emotional nutrients as a metaphor for a relationship's emotional needs avoids the word triggers that often lead to misunderstandings.

Which of all the nutrients is the most important and why?
Communication is by far the most important emotional nutrient in a relationship for the same reason water is the most important physical nutrient for the body. Without water, the body will die, and without communication, the relationship will become malnourished and die.

Why is it important for couples to identify problems early?
Identifying problems early in a relationship is crucial because it allows the couple to address issues before they become entrenched habits. Many relationship researchers agree that our relationships are governed by the underlying experiences we had in childhood. The theory is that, based on the experiences we may or may not have had as a child, these experiences will play out in the emotional patterns that grow out of our “core childhood wounds”. The argument is that we often let too many bothersome things go in the initial stages of a relationship because we are unaware of the significance of these core wounds in how we will relate to our partner. The metaphor used to explain this relationship dynamic is that the traits we bring to the relationship are like concrete– they can be shaped when the concrete is still fresh but quickly becomes rigid and almost impossible to change once it sets.

Going Green - Inifinity Lube™

As 2026’s hurricane season quickly approaches, experts are urging homeowners to check that their shutters are in tip-top shape to protect families, with some recommending shutter maintenance twice a year for optimal safety. Helping to reduce maintenance costs while enhancing efficiency is Sustainability Group (ISG) dba The Fuel Ox®, a New Jersey-based developer of numerous fuel additives and solutions (including breakthrough formula Infinity Lube™ Super Spray) devoted to alleviating consumer stress while advocating for sustainability. 


A recipient of both NSF and USDA-certification, rarities in the fuel industry, Infinity Lube™ Super Spray is a powerful lubricant, cutting fluid, and penetrant designed for external mechanical systems as well as metal surfaces. Capable of cleaning and degreasing, Infinity Lube™ is made from a specialty concentrate technology that loosen rust and frozen parts (freeing stuck nuts, bolts, and metal components with ease), provides superior barrier protection including shielding from abrasive contaminants (sand, salt, dirt, and mud, all prevalent during storms), offers Micron-Level Metal Conditioning (smooths and strengthens surfaces to reduce wear and extend equipment life), and gets into tiny spaces like bearings, hinges, and chains to protect from the inside out while staying intact longer than competitors on the market

“When The Fuel Ox was established, our goal was to help everyday consumers protect their homes as well as vehicles,” said Rand Taylor, CEO and Co-Founder. “With costs of living constantly rising, the average American doesn’t have the budget nor time for extensive maintenance. Our Infinity Lube™ takes these concerns out of the equation, allowing for quick improved protection while extending longevity of items such as shutters necessary for safety. We are very proud of our formulation, which has received notoriety for its power across the fuel sector.” 
According to Storm Smart, hurricane shutters are essential for preserving structural integrity and home safety, protecting doors and windows from glass-shattering winds. Many regions in the U.S., including Florida, require shutters as part of building codes, with many homeowners eligible to receive lower insurance costs for having them. Additionally, another article by Storm Smart discusses the importance of lubrication for hurricane shutters, with focus on maintenance yearly especially in more humid regions (as well as after a storm to clear out debris). 
Infinity Lube™ Super Spray can be purchased on The Fuel Ox’s website:

About The Fuel Ox®: 
The Fuel Ox® is an international corporation dedicated to providing fuel consumers with the most technologically advanced fuel treatments and lubricants on the market while helping them reduce their footprint on the environment with bio-based, eco-friendly and almost completely toxin-free products. Registered as Industrial Sustainability Group (ISG) and based in Asbury, NJ, The Fuel Ox manufactures fuel additives and lubricants to help improve fuel efficiency, operating life and performance of industrial equipment while reducing maintenance costs, equipment downtime, emissions, and pollutants. Its flagship products are Fuel Ox® with Combustion Catalyst and Infinity Lube™.

Area Attractions - Earth Month at Getty (LA)

 

Getty is kicking off Earth Month with an exciting slate of free public programs for all ages. From gallery tours focused on mindfulness, poetry in the Central Garden and a Roman garden seed ball workshop at the Getty Villa, there are plenty of ways visitors can celebrate the planet this month.

Earth Month evolved from Earth Day (April 22) to extend climate activism beyond a single day. It is a time dedicated to environmental education and sustainability.

“A healthy planet is key to our mission to preserve, learn from and share our collective heritage,” said Camille Kirk, director of sustainability at Getty. “We hope our visitors enjoy our offerings and will be inspired to take action after their visit—big or small, any effort to combat the climate crisis makes an impact.”

Visitors can enjoy a variety of gallery tours that focus on meditation and wellness, including Mindful Moment in the MuseumMoving MindfullyThe Breathe Tour and a brand-new Art & Nature tour offered exclusively for Earth Month that pairs Getty artworks with its outdoor spaces.

On April 12, Getty will present a full day of live poetry and music through its "Poetry in the Garden" series. Visitors are encouraged to bring a blanket and picnic, wander the Central Garden and relax as performances take place throughout the day.

Families can participate in hands-on art making activities in bilingual (English and Spanish) events such as Superpower Portraits: Collage Workshop and Roman Garden: Seed Ball Workshop.

The celebration will continue into May with Tastemakers: Earth Mother on May 9, which offers a culinary experience with a garden‑inspired brunch. Drawn from a Getty Research Institute cookbook, the program explores connections to the natural world and concludes with an immersive sound performance in the Central Garden that invites guests to experience ecology through taste, art and atmosphere.

Getty has been making strides to advance its sustainability work and build capacity in the cultural sector to take climate action. Efforts include Getty’s recent joint announcement with LACMA, MOCA, The Hammer and Hauser & Wirth to commit to the Bizot Green Protocol—a set of recommendations that offer environmentally sustainable approaches for the care of art collections. Other recent news includes the first-ever PST ART Climate Impact Program report and the Getty Global Art & Sustainability Fellows grant initiative.

Onsite, Getty offers electric vehicle charging stations, compostable food packaging, recycle and compost bins, upcycled Getty store items and more. Unused food items at the cafe are donated to Chefs to End Hunger.

For a full list of event dates and times, visit Getty’s Earth Month series page.

Read more sustainability related stories from Getty.

 

 

Getty advances art’s meaning and impact—bringing people together to preserve the past, inspire the present, and shape the future.

 

Visiting the Getty Center
The Getty Center is open Tuesday through Sunday, 10am to 6:30pm. The Getty Center is open until 9pm on Saturdays, year-round. It is closed Mondays, Thanksgiving, December 25 (Christmas Day), and January 1. Admission to the Getty Center is always free, but a reservation is required for admission. Make reservations online or at (310) 440-7300. Parking is $25 per car or motorcycle; $15 after 3pm; $10 after 6pm. Saturdays after 6pm, parking is free. The Getty Center is at 1200 Getty Center Drive, Los Angeles, California.

Visiting the Getty Villa
The Getty Villa is open Wednesday through Monday, 10am to 5pm. It is closed Tuesdays, Thanksgiving, December 25 (Christmas Day), and January 1. Admission to the Getty Villa is always free, but a reservation is required for admission. Make reservations online or at (310) 440-7300. Parking is $25, and $15 after 3pm. The Getty Villa is at 17985 Pacific Coast Highway, Pacific Palisades, California. 

Thursday, March 19, 2026

Money Matters - Where Gender Pay Gap is Closing

 As Equal Pay Day approaches (March 26, 2026), a new analysis highlights where earnings between men and women are closest and where women are now earning more than men in certain communities.

Best Money recently analyzed newly released U.S. Census earnings data to compare median annual earnings for full-time men and women across thousands of U.S. communities.

Key findings:

  • Leading the way with the highest ratio is Marlton, MD, with a ratio of 1.40. Within the Washington, D.C. metro area, women in Marlton earn a median salary of $100,525 while men take home $71,923.
  • In the Bend, OR, metro area of Crooked River Ranch, OR, the female earnings ratio is 1.40. Here, the median salary for women is $92,099, compared to the median salary for men of $65,714.
  • Coming in third for where women outearn men is Swannanoa, NC, within the Asheville, NC, metro area. With a median female earnings of $73,618 and median male earnings of $52,500, Swannanoa earns a ratio of 1.40.
  • Overall, Maryland, California, and New York have the most cities in the country where women outearn men.
  • Oakland, CA, and Los Angeles, CA, have the most equal pay among men and women in the U.S.
  • The Washington, D.C., metro area is home to the most suburbs with equal pay, claiming 10 of the top 25 spots.
While national discussions often focus on the overall gender pay gap, this analysis highlights where parity is already happening and where progress is most visible.

With economic pressures and workforce participation continuing to shape household finances, the cities closest to equal pay offer a real-world look at how earnings are evolving across the country.

Healthy Habits - Pollen and Asthma


As spring allergy season ramps up and pollen counts climb, millions of Americans with severe asthma face a higher risk of sudden, frightening flare-ups that can send them to the ER — even if they’re taking daily medication. 

 

An estimated 2 million Americans live with severe asthma, and more than 80% of people with severe asthma exhibit elevated levels of eosinophils (a type of white blood cell).  People living with severe asthma and an elevated level of eosinophils can experience frequent asthma attacks and may lead them to the emergency room or require a hospital stay.


In this interview, Dareen Siri, MD, Pediatric and Adult Allergy Asthma & Immunology, discusses severe asthma, risks associated with uncontrolled disease and a new option available designed to prevent asthma attacks.





Interview courtesy: GSK (References available)

 

 

About Exdensur (depemokimab-ulaa)

EXDENSUR is indicated for the add-on maintenance treatment of severe asthma, characterized by an eosinophilic phenotype, in adult and pediatric patients aged 12 years and older. EXDENSUR is not indicated for the relief of acute bronchospasm or status asthmaticus. 

 

Important Safety Information for EXDENSUR

 

WARNINGS AND PRECAUTIONS

 

Hypersensitivity Reactions

Hypersensitivity reactions, including anaphylaxis, can occur following administration of EXDENSUR. If a severe hypersensitivity reaction occurs, discontinue EXDENSUR and initiate appropriate therapy.

 

Acute Asthma Symptoms or Deteriorating Disease

EXDENSUR should not be used to treat acute asthma symptoms or acute exacerbations.

 

Risk Associated with Abrupt Reduction of Corticosteroid Dosage

Do not abruptly discontinue systemic or inhaled corticosteroids upon initiation of EXDENSUR therapy. Reductions in corticosteroid dose, if appropriate, should be gradual and under the supervision of a healthcare provider. Reduction in corticosteroid dose may be associated with systemic withdrawal symptoms and/or unmask conditions previously suppressed by systemic corticosteroid therapy.

 

Parasitic (Helminth) Infection

Patients with pre-existing helminth infections should be treated for their infection prior to initiation of EXDENSUR therapy. If patients become infected while receiving EXDENSUR and do not respond to anti-helminth treatment, discontinue EXDENSUR until the infection resolves.

 

ADVERSE REACTIONS

 

In patients receiving EXDENSUR, the most common adverse reactions (≥4%) were upper respiratory tract infection, allergic rhinitis, influenza, arthralgia, and pharyngitis. Injection site reactions reactions also occurred. 

 

USE IN SPECIFIC POPULATIONS

 

The data in pregnant women are insufficient to identify a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes. Transport of endogenous IgG antibodies and monoclonal antibodies, such as depemokimab-ulaa, across the placenta increases as pregnancy progresses and peaks during the third trimester.

 

The potential clinical impact of depemokimab-ulaa transmission to the fetus is unknown as the effect of YTE modification on placental transfer is uncertain and may lead to prolonged exposure in an infant. Pregnant women exposed to EXDENSUR, or their healthcare providers, should report EXDENSUR exposure by calling 1-888-825-5249.